Guidelines on the Clinical Management of Sepsis (2025)

30 January 2024

Departmental update

Reading time:

Treatment for sepsis can save lives. This needs high quality clinical care, especially in primary care clinics, and hospitals including emergency, critical and operative care areas.

The 70th World Health Assembly called for the development of guidance on sepsis prevention and management to support Members States in “Improving the prevention, diagnosis and clinical management of sepsis” [WHA resolution 70.7].2

Patients with sepsis need high quality care from the first point they reach medical services until they fully recover. Optimising their outcomes therefore involves early recognition, emergency care, targeted antimicrobial therapy, infection source control, intensive monitoring, detection of clinical deterioration, and prevention of organ failure and complications. Effective and efficient critical care and early operative care can further reduce mortality and morbidity.

This WHO guideline will use the best evidence to help patients and the healthcare workers looking after them.3 It will focus on making global recommendations for early recognition, initial resuscitation, and the early treatment of sepsis during which periods patients are most vulnerable.

The recommendations will support to Member States to develop and implement national programmes for the management of sepsis in adults and children. The wide intended audience includes health care workers (health professionals including doctors, nurses, intensivists/critical care staff, ambulance staff), policy-makers, their expert advisers and technical/ programme staff at organizations involved in the management of adults or children with sepsis.

Recommendations will be published as WHO guidelines, and will include tools to support implementation.

Disclaimers:

In order to enhance its management of Conflicts of Interest as well as strengthen public trust and transparency in connection with WHO meetings involving the provision of technical/normative advice, the names and brief biographies of individuals (“Published Information” ) being considered for participation in such meetings are disclosed for public notice and comment.

The Published Information is provided by the experts themselves and is the sole responsibility of the individuals concerned. WHO is not responsible for the accuracy, veracity and completeness of the Published Information provided. Furthermore, in no event will WHO be responsible or liable for damages in relation to the use of, and reliance upon, the Published Information.

The comments received by WHO through the public notice and comment process are treated confidentially and their receipt will be acknowledged through a generic email notification to the sender.Any comments should be sent to:sepsiscare@who.intbefore 4 March 2024, 12:00 CET.Comments and perceptions brought to the knowledge of WHO through this process are an integral component of WHO’s conflict of interest assessment policy and are carefully reviewed. WHO reserves the right to discuss information received through this process with the relevant expert with no attribution to the provider of such information. Upon review and assessment of the information received through this process, WHO, in its sole discretion, may take appropriate management action in accordance with its policies.

The participation of an expert in a WHO meeting does not imply that they are endorsed or recommended by the World Health Organization nor does it create a binding relationship between the expert and WHO.

The list of participating experts, a summary of relevant interests disclosed by such experts, and any appropriate mitigation measures taken by WHO relating to the management of conflicts of interests, will be reported publically in accordance with WHO practice.

","datePublished":"2024-01-30T05:00:00.0000000+00:00","image":"https://www.who.int/images/default-source/fallback/icons/news.png?sfvrsn=d88eddde_0","publisher":{"@type":"Organization","name":"World Health Organization: WHO","logo":{"@type":"ImageObject","url":"https://www.who.int/Images/SchemaOrg/schemaOrgLogo.jpg","width":250,"height":60}},"dateModified":"2024-01-30T05:00:00.0000000+00:00","mainEntityOfPage":"https://www.who.int/news/item/30-01-2024-guidelines-on-the-clinical-management-of-sepsis","@context":"http://schema.org","@type":"NewsArticle"};

Guidelines on the Clinical Management of Sepsis (2025)
Top Articles
Latest Posts
Recommended Articles
Article information

Author: Edwin Metz

Last Updated:

Views: 5964

Rating: 4.8 / 5 (78 voted)

Reviews: 85% of readers found this page helpful

Author information

Name: Edwin Metz

Birthday: 1997-04-16

Address: 51593 Leanne Light, Kuphalmouth, DE 50012-5183

Phone: +639107620957

Job: Corporate Banking Technician

Hobby: Reading, scrapbook, role-playing games, Fishing, Fishing, Scuba diving, Beekeeping

Introduction: My name is Edwin Metz, I am a fair, energetic, helpful, brave, outstanding, nice, helpful person who loves writing and wants to share my knowledge and understanding with you.